BDBM50297632 1-((1H-imidazol-2-yl)(phenyl)methyl)-3-(1-((1-(4-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methyl)piperidin-4-yl)urea::CHEMBL563791

SMILES O=C(NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)NC(c1ccccc1)c1ncc[nH]1

InChI Key InChIKey=PCLLBFUYVTXKME-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297632   

TargetMelanin-concentrating hormone receptor 1(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297632BDBM50297632(1-((1H-imidazol-2-yl)(phenyl)methyl)-3-(1-((1-(4-(...)
Affinity DataIC50: 27nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50297632BDBM50297632(1-((1H-imidazol-2-yl)(phenyl)methyl)-3-(1-((1-(4-(...)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297632BDBM50297632(1-((1H-imidazol-2-yl)(phenyl)methyl)-3-(1-((1-(4-(...)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human recombinant CYP3A4 after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed