BDBM50297909 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylbenzamide::CHEMBL552288

SMILES CN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1

InChI Key InChIKey=VZFUMZUWJFIKDW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297909   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50297909(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)
Affinity DataIC50:  638nMAssay Description:Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50297909(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mouse microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50297909(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50297909(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed