BDBM50298827 (S)-5-(3-(2',6'-diisopropyl-2-methoxybiphenyl-4-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::CHEMBL575176

SMILES COc1cc([C@H](C)C#Cc2c(C)nc(N)nc2N)ccc1-c1c(C(C)C)cccc1C(C)C

InChI Key InChIKey=NQBNSJKYKJECKP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298827   

TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298827BDBM50298827((S)-5-(3-(2',6'-diisopropyl-2-methoxybiphenyl-4-yl...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed