BDBM50299852 CHEMBL568073::N-(1-(3-(4-Methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine::US8772508, 13

SMILES Cc1cn(CCCNC(C[N+]([O-])=O)=Nc2ccc3OCCOc3c2)cn1

InChI Key InChIKey=KJIVXLFFKWSWIW-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50299852   

TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299852(CHEMBL568073 | US8772508, 13 | N-(1-(3-(4-Methyl-1...)
Affinity DataKi:  1.29E+3nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Probiodrug

US Patent
LigandPNGBDBM50299852(CHEMBL568073 | US8772508, 13 | N-(1-(3-(4-Methyl-1...)
Affinity DataIC50: 8.79E+3nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent