BDBM50299866 CHEMBL578153::N-(1-(3-(5-Methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-(trifluoromethyl)benzenamine::US8772508, 6

SMILES Cc1cncn1CCCN=C(C[N+]([O-])=O)Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=GPQHOIQTHKOAGY-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50299866   

TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299866(CHEMBL578153 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  34nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM50299866(CHEMBL578153 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  34nM IC50:  430nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent