BDBM50301520 4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide::CHEMBL566581
SMILES CC(C)Nc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1
InChI Key InChIKey=WIVGIKIKQHUFOD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50301520
TargetMetabotropic glutamate receptor 1(Rat)
National Institute of Radiological Sciences
Curated by ChEMBL
National Institute of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 5.40nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]quisqualate from human mGluR1 quisqualic acid binding siteMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human mGluR2 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Radiological Sciences
Curated by ChEMBL
National Institute of Radiological Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [11C]-ABP688 from mGluR5 in Sprague-Dawley rat brain homogenates after 1 hr by gamma countingMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Rat)
National Institute of Radiological Sciences
Curated by ChEMBL
National Institute of Radiological Sciences
Curated by ChEMBL
Affinity DataIC50: 13.9nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human mGluR8 receptorMore data for this Ligand-Target Pair