BDBM50302917 2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophenone::2-(tert-butylamino)-1-(3-chloro-4-methylphenyl)propan-1-one::CHEMBL565844

SMILES CC(NC(C)(C)C)C(=O)c1ccc(C)c(Cl)c1

InChI Key InChIKey=ABPSWEJOHYDZDP-UHFFFAOYSA-N

Data  3 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50302917   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataKi:  1.15E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human SERT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataKi:  5.10E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50:  410nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50:  9.20nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50: >100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50:  900nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50:  650nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50:  400nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50:  2.04E+3nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed