BDBM50303819 (R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol::CHEMBL584522

SMILES C[C@@](O)(C1CC1)[C@H]1CCCC2=Cc3c(ncn3C[C@]12C)-c1ccc(F)cc1

InChI Key InChIKey=BNACLTNZCKWBBX-UHFFFAOYSA-N

Data  1 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303819   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303819((R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5...)
Affinity DataKi:  2.60nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303819((R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5...)
Affinity DataEC50:  37nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303819((R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5...)
Affinity DataEC50:  49nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303819((R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5...)
Affinity DataIC50: 4.00E+3nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303819((R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5...)
Affinity DataEC50: >5.00E+3nMAssay Description:Transactivation of GAL-4 tagged glucocorticoid receptor ligand binding domain expressed in human HeLa cells assessed as NP1 activation by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed