BDBM50303834 Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl-5,5a ,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)methanol::Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl-5,5a,6, 7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)methanol::Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)methanol::CHEMBL569543

SMILES CC12Cn3cnc(c3C=C1CCCC2C(O)c1csc2ccccc12)-c1ccc(F)cc1

InChI Key InChIKey=GORYZYUNDWMPJM-UHFFFAOYSA-N

Data  4 KI  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50303834   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataKi:  7nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataKi:  134nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataKi:  134nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50:  910nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50:  920nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50:  1.01E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50:  1.02E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataKi: >1.15E+3nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50:  2.50E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303834(Benzo[b]thiophen-3-yl(1-(4-fluorophenyl)-5a-methyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed