BDBM50303987 CHEMBL4163417

SMILES Cc1c(-c2cccc3c(CCCOc4cccc5ccccc45)c(C(=O)O)[nH]c23)c(COc2ccc(B(O)O)cc2)nn1C

InChI Key InChIKey=NBAFNTUPZRZFCQ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303987   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303987BDBM50303987(CHEMBL4163417)
Affinity DataIC50: 162nMAssay Description:Inhibition of MCL-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303987BDBM50303987(CHEMBL4163417)
Affinity DataIC50: 162nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303987BDBM50303987(CHEMBL4163417)
Affinity DataIC50: 162nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303987BDBM50303987(CHEMBL4163417)
Affinity DataEC50: >1.10E+4nMAssay Description:Inhibition of MCL-1 in human MOLP8 cells assessed as increase in caspase 3/7 activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed