BDBM50304369 4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide::CHEMBL595583::US9320734, 104

SMILES CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1

InChI Key InChIKey=BYWWNRBKPCPJMG-UHFFFAOYSA-N

Data  3 KI  4 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50304369   

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKi:  2.40E+3nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKi:  2.40E+3nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of Akt phosphorylation in human BxPC3 cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDPK1 in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDPK1 in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDPK1 in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDPK1 in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDPK1 in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDPK1 in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKd:  1.35E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKd:  1.35E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKd:  4.08E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKd:  4.08E+4nMAssay Description:Inhibition of pleckstrin homology domain of AKT by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304369(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Affinity DataKd:  4.08E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent