BDBM50304391 (cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one::CHEMBL440878::cis-(+/-)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one::cis-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2Hphthalazin-1-one

SMILES COc1ccc(cc1OC)C1=NNC(=O)[C@@H]2CC=CC[C@H]12

InChI Key InChIKey=MRBFFQVXMIGKST-NWDGAFQWSA-N

Data  3 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50304391   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [125I]RTI-55 from human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [125I]RTI-55 from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PDE4 in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]NE reuptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50304391((cis)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed