BDBM50304490 CHEMBL611926::H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(CF3)2Bzl]

SMILES CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](CSSC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)NC(=O)[C@@H](N)Cc1ccc(O)cc1

InChI Key InChIKey=CYKFSGXEZOAASR-UHFFFAOYSA-N

Data  5 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50304490   

TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataEC50:  0.0170nMAssay Description:Agonist activity at human delta opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataIC50: 0.186nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at rat mu opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at rat mu opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataIC50: 85nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304490(H-Tyr-c[D-Cys-Gly-Phe-Nle-Pro-Cys]-Trp-NH-[3',5'-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed