BDBM50306158 3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-methyl-1H-pyrazolo[3,4-c]pyridin-5-yl)-6-(2-methylfuran-3-yl)pyridin-2-amine::CHEMBL595459

SMILES Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cc2c(C)n[nH]c2cn1

InChI Key InChIKey=AQJWACKPYCXBCF-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50306158   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human CK1alpha incubated for 30 mins in presence of ATP by ADP-GLO reagent based multimode microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine protein kinase YCK2(Candida albicans (strain SC5314 / ATCC MYA-2876) (...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant Yck2 in Candida albicans incubated for 30 mins in presence of ATP by ADP-GLO reagent based multimode microplate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 620nMAssay Description:Inhibition of human CK1epsilon transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K8 tracer by NanoBRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 680nMAssay Description:Inhibition of GSK2beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human P38alpha incubated for 30 mins in presence of ATP by ADP-GLO reagent based multimode microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human CK1delta transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K10 tracer by NanoBRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine protein kinase YCK2(Candida albicans (strain SC5314 / ATCC MYA-2876) (...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of N-terminal NLuc fused YCK2 (S37 to N345 residues) in Candida albicans transfected in HEK293 cells using NanoBRET NanoGlo substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed