BDBM50312775 (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3'-fluorobiphenyl-4-yl)methanone::CHEMBL1082210

SMILES C[C@H]1CN(CCN1C(=O)c1ccc2cc[nH]c2c1)C(=O)c1ccc(cc1)-c1cccc(F)c1

InChI Key InChIKey=LGKIWGDJKNJYMG-SFHVURJKSA-N

Data  12 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50312775   

LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D2 rceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2C(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2C (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of alpha2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D3 rceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataIC50:  147nMAssay Description:Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash lum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed