BDBM50313807 CHEMBL1093749::N-methyl-4-(3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl)benzenesulfonamide::N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide

SMILES CNS(=O)(=O)c1ccc(cc1)-c1cccc2ncc(nc12)-c1cc(OC)c(OC)c(OC)c1

InChI Key InChIKey=LYSCAOWDVVWGQK-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50313807   

TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313807(CHEMBL1093749 | N-methyl-4-(3-(3,4,5-trimethoxyphe...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant GST tagged JAK1 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313807(CHEMBL1093749 | N-methyl-4-(3-(3,4,5-trimethoxyphe...)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313807(CHEMBL1093749 | N-methyl-4-(3-(3,4,5-trimethoxyphe...)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant GST tagged JAK2 after 60 mins by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313807(CHEMBL1093749 | N-methyl-4-(3-(3,4,5-trimethoxyphe...)
Affinity DataIC50:  640nMAssay Description:Inhibition of recombinant GST tagged TYK2 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313807(CHEMBL1093749 | N-methyl-4-(3-(3,4,5-trimethoxyphe...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant GST tagged JAK3 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed