BDBM50314076 5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine::CHEMBL1093099::US9422297, AAG-148-43

SMILES Nc1nc(N)c2c(n1)[nH]c1cccc(Sc3ccccc3)c21

InChI Key InChIKey=DXZCXZCCPLYVDG-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50314076   

TargetThymidylate synthase(Human)
Duquesne University of The Holy Ghost

US Patent
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 540nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetThymidylate synthase(Human)
Duquesne University of The Holy Ghost

US Patent
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University of The Holy Ghost

US Patent
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Duquesne University of The Holy Ghost

US Patent
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Ghost

US Patent
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetThymidylate synthase(Escherichia coli (strain K12))
Duquesne University of The Holy Ghost

US Patent
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50314076BDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed