BDBM50314222 (R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(hydroxyamino)-4-oxobutylcarbamate::CHEMBL1089842

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](CCNC(=O)OCc1ccccc1)C(=O)NO

InChI Key InChIKey=YAYGKNVDBLFWFW-HXUWFJFHSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50314222   

TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  46nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  420nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  420nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  890nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  53nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant ADAM10 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  966nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  419nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed