BDBM50314224 (R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)-N-hydroxybutanamide::CHEMBL1088878

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H](CCN1C(=O)c2ccccc2C1=O)C(=O)NO

InChI Key InChIKey=WMJKIJLFVOMJDF-HSZRJFAPSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50314224   

TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314224((R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonami...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314224((R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonami...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50314224((R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonami...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant ADAM10 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314224((R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonami...)
Affinity DataIC50:  21nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50314224((R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonami...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314224((R)-2-(4-(but-2-ynyloxy)-N-isobutylphenylsulfonami...)
Affinity DataIC50:  400nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed