BDBM50314749 1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbonyl}amino)ethyl]-3-(trifluoromethyl)-1Hpyrazole-4-carboxamide hydrochloride::CHEMBL1090842

SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(cc1)-n1cccn1)-c1ccccc1

InChI Key InChIKey=SSBTXFRGIJAASG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314749   

TargetDiacylglycerol O-acyltransferase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314749(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314749(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Affinity DataIC50: 400nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed