BDBM50315275 2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)imidazo[1,2-a]pyridine::CHEMBL1088866

SMILES CCn1cnc(CN2CCN(CC2)c2cccn3cc(nc23)-c2ccc(cc2)C(C)(C)C)c1C

InChI Key InChIKey=XOVVOPXYEWLASI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315275   

TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315275(2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50: 6.70nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315275(2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315275(2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315275(2-(4-tert-butylphenyl)-8-(4-((1-ethyl-5-methyl-1H-...)
Affinity DataIC50: 420nMAssay Description:Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibition of D-Trp6-GnRH-induced LH accumulation after 3 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed