BDBM50315405 1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridine]-2-yl)methyl)-1,2,2a,3-tetrahydropyrrolo[4,3,2-de]quinolin-4(5H)-one::CHEMBL1092837

SMILES O=C1Nc2ncccc2[C@]11Cc2cc3ccc(CN4CC5CC(=O)Nc6cccc4c56)nc3cc2C1

InChI Key InChIKey=QPMNQIHFIPFQSE-CFLNXXHPSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50315405   

LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataIC50:  4.10nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataIC50:  0.860nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed