BDBM50315561 (R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate::CHEMBL1090829

SMILES C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1

InChI Key InChIKey=RMDMQWBLROBEJO-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50315561   

TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315561BDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataIC50: 6.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315561BDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataIC50: 9.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315561BDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataEC50:  22.4nMAssay Description:Antagonist activity at human S1P1 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315561BDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataIC50: 184nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315561BDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataEC50: >3.00E+3nMAssay Description:Antagonist activity at human S1P3 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315561BDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed