BDBM50315993 CHEMBL1091605::N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexyl)-2-oxopyrrolidin-3-yl)-3-(trifluoromethyl)benzamide

SMILES CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccccc2)C1)N1CC[C@H](NC(=O)c2cccc(c2)C(F)(F)F)C1=O

InChI Key InChIKey=JCEIOJXARAMKNB-JZUMHQTLSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50315993   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]-labeled human MCP1 from CCR2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human ERG by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human ERG by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 45 mins in presence of 0.1 M bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed