BDBM50316360 2-(5-{[(2S)-2-Amino-3-pyridin-4-ylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine::CHEMBL1097973

SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccncc2)c1

InChI Key InChIKey=YBRYILPNEOTARN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50316360   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316360(2-(5-{[(2S)-2-Amino-3-pyridin-4-ylpropyl]oxy}pyrid...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316360(2-(5-{[(2S)-2-Amino-3-pyridin-4-ylpropyl]oxy}pyrid...)
Affinity DataIC50: 343nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316360(2-(5-{[(2S)-2-Amino-3-pyridin-4-ylpropyl]oxy}pyrid...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed