BDBM50318127 (15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-triazatetracyclo[14.5.3.1^{3,7}.0^{19,23}]pentacosa-1(22),3(25),4,6,17,19(23),20-heptaen-12-one::CHEMBL1098734

SMILES NC1=Nc2ccc3Oc4cccc(CCCN(C5CCCCC5)C(=O)CC[C@@H](C5CCCCC5)N1Cc2c3)c4

InChI Key InChIKey=YRZGWNOJFXJXID-HKBQPEDESA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50318127   

TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  31nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataIC50:  34nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed