BDBM50318462 4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)ethyl)benzamide::CHEMBL1086589

SMILES Cc1ccc(cc1)C(=O)NC(Sc1ccc(cc1)[N+]([O-])=O)C(Cl)(Cl)Cl

InChI Key InChIKey=XFAKQJSOOQVAHX-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50318462   

LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of trinitrophenol-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 560nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of hypertonic solution of 400 mOsm-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of URB597-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataEC50:  880nMAssay Description:Agonist activity at full length rat TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataEC50:  930nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at full length human TRPA1 transfected in HEK293F cells assessed as blockade of MO-induced TRPA1 channel activation by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of 4-hydroxy-2-nonenal-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of cynnamaldehyde-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 2.70E+3nMAssay Description:Antagonist activity at full length rhesus monkey TRPA1 transfected in HEK293F cells assessed as blockade of MO-induced TRPA1 channel activation by me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed