BDBM50319163 8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine::CHEMBL1085374

SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12

InChI Key InChIKey=WYHTXPAKFZNNJB-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50319163   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  69nMAssay Description:Inhibition of PDE11AMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  561nMAssay Description:Inhibition of PDE5AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  7.20nMAssay Description:Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair

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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of PDE2AMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE1BMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50:  69nMAssay Description:Inhibition of PDE11AMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Biotie Therapies

Curated by ChEMBL

LigandBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE9AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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