BDBM50319454 1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl)-3-(1-methyl-1H-indazol-4-yl)urea::CHEMBL1085324

SMILES Cn1ncc2c(NC(=O)NCc3ccc(cc3CCC(C)(C)C)C(F)(F)F)cccc12

InChI Key InChIKey=SMJCAASNPAKOIB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319454   

LigandPNGBDBM50319454(1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...)
Affinity DataIC50: 7nMpH: 5.5Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced effect at pH 5.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319454(1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of N-arachidonoyl-dopamine-induced effectMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319454(1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...)
Affinity DataIC50: 277nMAssay Description:Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced effectMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed