BDBM50319631 CHEMBL1083134::trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride

SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1

InChI Key InChIKey=IYOZTVGMEWJPKR-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50319631   

TargetRho-associated protein kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataKi:  140nMAssay Description:Inhibition of p160ROCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 700nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S/A2016T mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed