BDBM50319716 (3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide::CHEMBL1082821

SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl

InChI Key InChIKey=XBFAFSAUQFDEOK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319716   

TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 14nMAssay Description:Inhibition of PRKCL2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 24nMAssay Description:Inhibition of PRKG2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCell division control protein 42 homolog(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 54nMAssay Description:Inhibition of CDC42More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKCEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed