BDBM50319841 (S)-4-(1-(1-(3-(trifluoromethyl)benzyl)-1H-indole-7-carboxamido)ethyl)benzoic acid::CHEMBL1084551

SMILES C[C@H](NC(=O)c1cccc2ccn(Cc3cccc(c3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O

InChI Key InChIKey=OJSYHQJJZVGGBN-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319841   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50319841((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)-1H-indole-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50319841((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)-1H-indole-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50319841((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)-1H-indole-...)
Affinity DataKi:  885nMAssay Description:Displacement of [3H]PGD2 from human Prostanoid DP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed