BDBM50321256 1-tosyl-1H-pyrrol-2(5H)-one::CA inhibitor, 15::CHEMBL1163131

SMILES Cc1ccc(cc1)S(=O)(=O)N1CC=CC1=O

InChI Key InChIKey=RFSWKQLTYZGQPP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50321256   

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50321256(1-tosyl-1H-pyrrol-2(5H)-one | CA inhibitor, 15 | C...)
Affinity DataKi:  406nM ΔG°:  -8.71kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50321256(1-tosyl-1H-pyrrol-2(5H)-one | CA inhibitor, 15 | C...)
Affinity DataKi:  534nM ΔG°:  -8.55kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50321256(1-tosyl-1H-pyrrol-2(5H)-one | CA inhibitor, 15 | C...)
Affinity DataKi:  2.31E+4nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50321256(1-tosyl-1H-pyrrol-2(5H)-one | CA inhibitor, 15 | C...)
Affinity DataKi:  3.73E+4nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 1 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed