BDBM50321257 5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one::CA inhibitor, 16::CHEMBL1163554

SMILES Cc1ccc(cc1)S(=O)(=O)N1C(O)C=CC1=O

InChI Key InChIKey=LASNBXWNXQRYSO-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50321257   

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Atat£Rk University

Curated by ChEMBL
LigandPNGBDBM50321257(5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | CA inhibit...)
Affinity DataKi:  510nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Atat£Rk University

Curated by ChEMBL
LigandPNGBDBM50321257(5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | CA inhibit...)
Affinity DataKi:  584nM ΔG°:  -8.50kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50321257(5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | CA inhibit...)
Affinity DataKi:  639nM ΔG°:  -8.44kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50321257(5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | CA inhibit...)
Affinity DataKi:  1.46E+4nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 1 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed