BDBM50322950 2-(3-chloro-4-fluorophenyl)-7-(5-fluoro-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-(pyridin-2-yl)-2,7-diazaspiro[3.5]nonan-1-one::CHEMBL1210902

SMILES O=C1N(c2ccc(F)c(Cl)c2)C(c2ccccn2)C12CCN(c1nc3cc(C(F)(F)F)c(F)cc3[nH]1)CC2

InChI Key InChIKey=XVGFCIHXNZUCGJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50322950   

TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322950BDBM50322950(2-(3-chloro-4-fluorophenyl)-7-(5-fluoro-6-(trifluo...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322950BDBM50322950(2-(3-chloro-4-fluorophenyl)-7-(5-fluoro-6-(trifluo...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322950BDBM50322950(2-(3-chloro-4-fluorophenyl)-7-(5-fluoro-6-(trifluo...)
Affinity DataIC50: 106nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by whole cell path clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed