BDBM50323258 6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile::CHEMBL1208910::US9115126, WO 2009/010491, Example 15

SMILES Cn1cnc2c(nc(cc12)-c1ccc(CCCO)c(c1)C(F)(F)F)C#N

InChI Key InChIKey=JDJQLDQXYPUJRN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323258   

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323258(6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  234nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323258(6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323258(6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed