BDBM50324284 (Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl}propanoic Acid::CHEMBL1214783

SMILES OC(=O)CCc1c(C=C2C(=O)Nc3ccc(F)cc23)[nH]c2CCCC(=O)c12

InChI Key InChIKey=WMBHFEGLMDPHMG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324284   

TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal 6-His tagged recombinant VEGFR2 Kinase domain (unknown origin) expressed in baculovirus expression system incubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 42nMAssay Description:Inhibition of N-terminal 6-His tagged recombinant PDGFRbeta Kinase domain (unknown origin) expressed in baculovirus expression system incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 178nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal 6-His tagged recombinant FGFR1 Kinase domain (unknown origin) expressed in baculovirus expression system incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed