BDBM50325374 (S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide::CHEMBL1222565

SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl

InChI Key InChIKey=LRTVAHMMILMPNA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50325374   

LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 320nMAssay Description:Inhibition of purified His-tagged IKK-beta after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant IKKalpha after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of recombinant CDK2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant JNK3 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant PDK1 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant p38alpha after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50325374((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant GSK3-beta after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed