BDBM50325451 1-(1-(1-(pyridin-4-ylmethyl)piperidine-4-carbonyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one::CHEMBL1222485

SMILES O=C(C1CCN(Cc2ccncc2)CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O

InChI Key InChIKey=JPGAOJPEVJFAIQ-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50325451   

TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325451(1-(1-(1-(pyridin-4-ylmethyl)piperidine-4-carbonyl)...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325451(1-(1-(1-(pyridin-4-ylmethyl)piperidine-4-carbonyl)...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325451(1-(1-(1-(pyridin-4-ylmethyl)piperidine-4-carbonyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325451(1-(1-(1-(pyridin-4-ylmethyl)piperidine-4-carbonyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed