BDBM50325871 CHEMBL1224215::endo-4-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)-3-methylbenzamide

SMILES Cc1cc(C(N)=O)ccc1O[C@H]1C[C@H]2CC[C@@H](C1)N2Cc1ccccc1

InChI Key InChIKey=DIBOAEDLUWGCBT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50325871   

TargetMu-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325871BDBM50325871(endo-4-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-...)
Affinity DataIC50: 419nMAssay Description:Antagonist activity at human mu opioid receptor expressed in HEK cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325871BDBM50325871(endo-4-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-...)
Affinity DataIC50: 462nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50325871BDBM50325871(endo-4-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed