BDBM50325873 CHEMBL1224217::endo-6-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)nicotinamide

SMILES NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)nc1

InChI Key InChIKey=JFWPMQLTKWIWER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50325873   

LigandChemical structure of BindingDB Monomer ID 50325873BDBM50325873(endo-6-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325873BDBM50325873(endo-6-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-...)
Affinity DataIC50: 1.93E+4nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed