BDBM50326206 CHEMBL1243200::N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1

InChI Key InChIKey=YRIZEPGWRQGUBO-UHFFFAOYSA-N

Data  17 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50326206   

TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataEC50:  15nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IGFR1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Zap70 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of BTK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PLK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed