BDBM50326938 1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-furo[2,3-c]pyridin-2-ylmethyl-4-methylpentan-2-ol::CHEMBL1254906

SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccncc2o1)C(F)(F)F

InChI Key InChIKey=FJNNUNSQTYMTMN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50326938   

TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326938(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-fur...)
Affinity DataIC50: 22nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326938(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-fur...)
Affinity DataIC50: 1.05E+3nMAssay Description:Binding affinity to mineralocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326938(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-fur...)
Affinity DataIC50: 2.00E+3nMAssay Description:Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326938(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-fur...)
Affinity DataIC50: 2.00E+3nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed