BDBM50327248 CHEMBL1257821::endo-3-(8-(4-methylbenzyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)cc1

InChI Key InChIKey=NBCIMSDAMDKCQO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327248   

LigandChemical structure of BindingDB Monomer ID 50327248BDBM50327248(endo-3-(8-(4-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327248BDBM50327248(endo-3-(8-(4-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327248BDBM50327248(endo-3-(8-(4-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 482nMAssay Description:Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327248BDBM50327248(endo-3-(8-(4-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 1.09E+4nMAssay Description:Antagonist activity at human delta opioid receptor assessed as inhibition of SNC80-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed