BDBM50327262 CHEMBL1258392::endo-3-(8-((1-methyl-1H-pyrazol-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES Cn1cc(CN2[C@H]3CC[C@@H]2C[C@H](C3)Oc2cccc(c2)C(N)=O)cn1

InChI Key InChIKey=UXSVZYNPXQBZKE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327262   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327262(endo-3-(8-((1-methyl-1H-pyrazol-4-yl)methyl)-8-aza...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327262(endo-3-(8-((1-methyl-1H-pyrazol-4-yl)methyl)-8-aza...)
Affinity DataIC50: 524nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327262(endo-3-(8-((1-methyl-1H-pyrazol-4-yl)methyl)-8-aza...)
Affinity DataIC50: 9.43E+3nMAssay Description:Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327262(endo-3-(8-((1-methyl-1H-pyrazol-4-yl)methyl)-8-aza...)
Affinity DataIC50: 2.73E+4nMAssay Description:Antagonist activity at human delta opioid receptor assessed as inhibition of SNC80-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed