BDBM50327267 CHEMBL1258724::endo-3-(8-(1-o-tolylethyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES Cc1ccccc1C(C)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2

InChI Key InChIKey=IQTXUDCVFFYTOM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50327267   

LigandChemical structure of BindingDB Monomer ID 50327267BDBM50327267(endo-3-(8-(1-o-tolylethyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327267BDBM50327267(endo-3-(8-(1-o-tolylethyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 846nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327267BDBM50327267(endo-3-(8-(1-o-tolylethyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 1.68E+4nMAssay Description:Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed