BDBM50328586 1-(4-(4-([3,6'-biquinolin]-4'-ylamino)-2-(trifluoromethyl)phenyl)piperazin-1-yl)-3-methoxypropan-1-one::CHEMBL1256447

SMILES COCCC(=O)N1CCN(CC1)c1ccc(Nc2ccnc3ccc(cc23)-c2cnc3ccccc3c2)cc1C(F)(F)F

InChI Key InChIKey=VHLFKLWNRISGKS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328586   

TargetSerine/threonine-protein kinase mTOR(Mouse)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328586(1-(4-(4-([3,6'-biquinolin]-4'-ylamino)-2-(trifluor...)
Affinity DataIC50: 300nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50328586(1-(4-(4-([3,6'-biquinolin]-4'-ylamino)-2-(trifluor...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells expressing Akt1 S473D mutant assessed as phosphorylation of Akt Thr308 by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328586(1-(4-(4-([3,6'-biquinolin]-4'-ylamino)-2-(trifluor...)
Affinity DataIC50: 966nMAssay Description:Binding affinity to mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed