BDBM50328597 CHEMBL1256454::N-(4-(2-oxo-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,2-dihydrobenzo[h][1,6]naphthyridin-9-yl)phenyl)methanesulfonamide(

SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc2ncc3ccc(=O)n(-c4ccc(N5CCNCC5)c(c4)C(F)(F)F)c3c2c1

InChI Key InChIKey=LETHISNIFGITRE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328597   

TargetSerine/threonine-protein kinase mTOR(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328597(N-(4-(2-oxo-1-(4-(piperazin-1-yl)-3-(trifluorometh...)
Affinity DataIC50: 46nMAssay Description:Binding affinity to mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Mouse)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328597(N-(4-(2-oxo-1-(4-(piperazin-1-yl)-3-(trifluorometh...)
Affinity DataIC50: 300nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed