BDBM50329648 2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-carboxylate::CHEMBL1270741

SMILES Fc1cc(F)c(OC(=O)c2cc3c(cn2)[nH]c2ccccc32)cc1F

InChI Key InChIKey=RFYCGFKOGLYZKJ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50329648   

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329648(2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-car...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329648(2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-car...)
Affinity DataKi:  44.8nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329648(2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-car...)
Affinity DataKi:  177nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329648(2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-car...)
Affinity DataKi:  422nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-5-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA A receptor alpha-4/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329648(2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-car...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-4-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329648(2,4,5-trifluorophenyl 9H-pyrido[3,4-b]indole-3-car...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-6-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed