BDBM50330249 6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-methylphenethyl)-2,2'-binaphthyl-1,1',4,4'-tetraone::CHEMBL1269076

SMILES Cc1ccc(CC=c2c(O)c(O)cc3c(O)c(-c4c(O)c5cc(O)c(O)c(=CCc6ccc(C)cc6)c5c(O)c4=C)c(=C)c(O)c23)cc1

InChI Key InChIKey=HYFIYBVLICZNBT-UHFFFAOYSA-N

Data  4 KI  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50330249   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataKi:  1.37E+3nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataIC50: 2.05E+3nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataKi:  2.07E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataKi:  2.08E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity Bcl-xL by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataIC50: 3.10E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataIC50: 3.12E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataKi:  9.33E+3nMAssay Description:Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataIC50: 1.47E+4nMAssay Description:Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed